Well, Portugal’s mine now. At this point, anything that’s vassalizable by war is too small to be a threat. And in this case, Portugal’s allies dropped the ball too.
With Portugal now in the fold, I want to brutalize Castille again. The idea is to feed Portugal provinces so that it’s big enough to colonize efficiently, and to reduce Castille to a vassalizable size. Then it’ll be more than time to let the Christians forget about me.
This start a longer-than-expected sequence of wars. I weaken Castille enough that Aragon declares independence. Then I end up fighting Aragon, just to put them at truce since their AE is so high from my smashing of Portugal and Castille. In there, I also fight the Mamluks again, and Qara Qoyunlu. And some minor countries here and there. And then I do it again. And again, and again.
Eventually, I vassalize Castille (which will keep on hating me for a long, long time, what with their -450 or so AE against me.) I also start cutting Aragon just to keep them at truce.
Somewhere in there, France loses a war and ends up having to break our alliance – which means they now start to get pissed at me for conquering their neighbors. It’s not dramatic (they’ll calm down enough before our truce runs out) but it means we’re done pissing Europe off for a long, good while. Which means the puzzle becomes “how can I begin expanding in Asia without making more angry enemies.”